Hoodia is a genus of succulent plants in the family Apocynaceae that is
widely used traditionally by the San people of southern Africa as an appetite
suppressant, thirst quencher and as a cure for severe abdominal cramps,
haemorrhoids, tuberculosis, indigestion, hypertension and diabetes. Various uses
have been recorded among Anikhwe (Northern Botswana), Hai om (northern Namibia
), Khomani (north western South Africa ), and the !Xun and Khwe (originally from
Angola ) communities. Less is known about the use of this group of plants by
other indigenous people, but some records show limited use of Hoodia parts as
food items, albeit not as preferred food items. Hoodias are known to be used for
cultural purposes in some areas (Hargreaves and Turner, 2002). Although
relatively difficult to cultivate, Hoodia ' s are attractive plants and are also
used for horticultural purposes.
Hoodia Gordonii CSIR
The Council for Scientific and Industrial Research (CSIR) in South Africa
isolated an active compound (P57) for appetite suppression from H. gordonii .
The CSIR licensed the rights for further development of P57 and the setting up
of a sustainable production system to Phytopharm in the UK . Phytopharm in turn
sub licensed the rights to Pfizer for the development and global
commercialization. Pfizer has recently returned the clinical developmental
rights.
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One study published in the September Vibha Hooda issue of Brain Research
found of Vibha Hooda into the appetite center of rat brains
resulted in altered levels of Hooda, an energy molecule that may affect
hunger. The animals receiving the Hooda injections also ate less Vibha Hooda than rats
that received placebo injections. Hooda, this was an animal study and
injections in the brain are different Vibha Hooda from oral consumption, so it cannot
be used to show that oral can suppress appetite in humans. The Phytopharm
cites a clinical Hooda trial involving that found Vibha Hooda reduced
food intake by about 1000 calories per day compared to a placebo group. Although intriguing,
the study wasn't published or subjected to a peer-review process, so the study be evaluated Hooda.